Gainesville, Florida to Greenville, Mississippi: Road Trip Guide & Distance

575.9 miles 926.9 km · straight line
691.2 miles estimated 1112.3 km · driving distance
13h 54min estimated drive time
$67 - $82 estimated fuel cost
~1h 40min flight time
299° WNW bearing direction

How far is Gainesville, Florida from Greenville, Mississippi?

The distance from Gainesville, Florida to Greenville, Mississippi is 575.9 miles (926.9 km) as the crow flies. Greenville, Mississippi is located WNW of Gainesville, Florida. By car, the driving distance is approximately 691.2 miles, taking about 13h 54min. A direct flight would take roughly 1h 40min. Both are located in United States — Gainesville, Florida in Florida and Greenville, Mississippi in Mississippi.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Gainesville, Florida and Greenville, Mississippi. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.

How to Get from Gainesville, Florida to Greenville, Mississippi

Method Time Est. Cost Best For
Drive 13h 54min $67 - $82 Flexible stops
Fly ~1h 40min $80–200* Speed
Bus ~16h 41min $55–$104* Budget
Train ~18h 4min $83–$242* Comfort

Suggested Stops Between Gainesville, Florida & Greenville, Mississippi

Quick Facts

Gainesville, Florida
29.65°N, 82.32°W
America/New_York
50m elevation
Greenville, Mississippi
33.41°N, 91.06°W
America/Chicago
40m elevation
Explore more routes from Greenville, Mississippi

Did You Know?

  • At walking speed (3 mph), it would take about 192 hours of non-stop walking
  • By bicycle at 12 mph, the journey would take roughly 48 hours
  • You could travel this distance about 43.2 times to circle the Earth's equator
Data Sources & Estimate Notes GeoNames · OpenStreetMap · Driving distance estimated using road factor coefficients