Florence, South Carolina to Port Saint Lucie: Road Trip Guide & Distance

How far is Florence, South Carolina from Port Saint Lucie?

The distance from Florence, South Carolina to Port Saint Lucie is 478.1 miles (769.5 km) as the crow flies. Port Saint Lucie is located S of Florence, South Carolina. By car, the driving distance is approximately 573.8 miles, taking about 11h 33min. A direct flight would take roughly 1h 28min. Both are located in United States — Florence, South Carolina in South Carolina and Port Saint Lucie in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Florence, South Carolina and Port Saint Lucie. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.