Charleston, South Carolina to Port Saint Lucie: Road Trip Guide & Distance

How far is Charleston, South Carolina from Port Saint Lucie?

The distance from Charleston, South Carolina to Port Saint Lucie is 379.7 miles (611 km) as the crow flies. Port Saint Lucie is located S of Charleston, South Carolina. By car, the driving distance is approximately 455.6 miles, taking about 9h 10min. A direct flight would take roughly 1h 16min. Both are located in United States — Charleston, South Carolina in South Carolina and Port Saint Lucie in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Charleston, South Carolina and Port Saint Lucie. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.