Florence, South Carolina to Gainesville, Florida: Road Trip Guide & Distance

How far is Florence, South Carolina from Gainesville, Florida?

The distance from Florence, South Carolina to Gainesville, Florida is 348 miles (560.1 km) as the crow flies. Gainesville, Florida is located SSW of Florence, South Carolina. By car, the driving distance is approximately 417.6 miles, taking about 8h 24min. A direct flight would take roughly 1h 12min. Both are located in United States — Florence, South Carolina in South Carolina and Gainesville, Florida in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Florence, South Carolina and Gainesville, Florida. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.