Florence, South Carolina to Jacksonville, Florida: Road Trip Guide & Distance

How far is Florence, South Carolina from Jacksonville, Florida?

The distance from Florence, South Carolina to Jacksonville, Florida is 288.9 miles (465 km) as the crow flies. Jacksonville, Florida is located SSW of Florence, South Carolina. By car, the driving distance is approximately 308.1 miles, taking about 5h 40min. A direct flight would take roughly 1h 5min. Both are located in United States — Florence, South Carolina in South Carolina and Jacksonville, Florida in Florida.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Florence, South Carolina and Jacksonville, Florida. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.