Edwardsville to Tupelo: Road Trip Guide & Distance

How far is Edwardsville from Tupelo?

The distance from Edwardsville to Tupelo is 322.1 miles (518.4 km) as the crow flies. Tupelo is located SSE of Edwardsville. By car, the driving distance is approximately 386.6 miles, taking about 7h 47min. A direct flight would take roughly 1h 9min. Both are located in United States — Edwardsville in Illinois and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Edwardsville and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.