Edwardsville to Kirksville: Road Trip Guide & Distance

How far is Edwardsville from Kirksville?

The distance from Edwardsville to Kirksville is 169.7 miles (273.1 km) as the crow flies. Kirksville is located NW of Edwardsville. By car, the driving distance is approximately 212.1 miles, taking about 4h 16min. A direct flight would take roughly 50min. Both are located in United States — Edwardsville in Illinois and Kirksville in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for Edwardsville and Kirksville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.