Durham, North Carolina to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Durham, North Carolina from O'Fallon, Missouri?

The distance from Durham, North Carolina to O'Fallon, Missouri is 675.7 miles (1087.5 km) as the crow flies. O'Fallon, Missouri is located WNW of Durham, North Carolina. By car, the driving distance is approximately 810.9 miles, taking about 16h 19min. A direct flight would take roughly 1h 52min. Both are located in United States — Durham, North Carolina in North Carolina and O'Fallon, Missouri in Missouri.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Durham, North Carolina and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.