O'Fallon, Missouri to Winston-Salem: Road Trip Guide & Distance

602.9 miles 970.2 km · straight line
723.4 miles estimated 1164.2 km · driving distance
14h 33min estimated drive time
$70 - $86 estimated fuel cost
~1h 43min flight time
105° ESE bearing direction

How far is O'Fallon, Missouri from Winston-Salem?

The distance from O'Fallon, Missouri to Winston-Salem is 602.9 miles (970.2 km) as the crow flies. Winston-Salem is located ESE of O'Fallon, Missouri. By car, the driving distance is approximately 723.4 miles, taking about 14h 33min. A direct flight would take roughly 1h 43min. Both are located in United States — O'Fallon, Missouri in Missouri and Winston-Salem in North Carolina.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for O'Fallon, Missouri and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.

How to Get from O'Fallon, Missouri to Winston-Salem

Method Time Est. Cost Best For
Drive 14h 33min $70 - $86 Flexible stops
Fly ~1h 43min $80–200* Speed
Bus ~17h 28min $58–$109* Budget
Train ~18h 55min $87–$253* Comfort

Suggested Stops Between O'Fallon, Missouri & Winston-Salem

Quick Facts

O'Fallon, Missouri
38.81°N, 90.70°W
America/Chicago
165m elevation
Winston-Salem
36.10°N, 80.24°W
America/New_York
293m elevation
Explore more routes from Winston-Salem

Did You Know?

  • At walking speed (3 mph), it would take about 201 hours of non-stop walking
  • By bicycle at 12 mph, the journey would take roughly 50 hours
  • You could travel this distance about 41.3 times to circle the Earth's equator
Data Sources & Estimate Notes GeoNames · OpenStreetMap · Driving distance estimated using road factor coefficients