Durham, North Carolina to Knoxville: Road Trip Guide & Distance

How far is Durham, North Carolina from Knoxville?

The distance from Durham, North Carolina to Knoxville is 280.8 miles (451.9 km) as the crow flies. Knoxville is located W of Durham, North Carolina. By car, the driving distance is approximately 351 miles, taking about 7h 4min. A direct flight would take roughly 1h 4min. Both are located in United States — Durham, North Carolina in North Carolina and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Durham, North Carolina and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.