Columbia, Missouri to Tupelo: Road Trip Guide & Distance

How far is Columbia, Missouri from Tupelo?

The distance from Columbia, Missouri to Tupelo is 381.6 miles (614.2 km) as the crow flies. Tupelo is located SSE of Columbia, Missouri. By car, the driving distance is approximately 458 miles, taking about 9h 13min. A direct flight would take roughly 1h 16min. Both are located in United States — Columbia, Missouri in Missouri and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Columbia, Missouri and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.