Cleveland, Ohio to Knoxville: Road Trip Guide & Distance

How far is Cleveland, Ohio from Knoxville?

The distance from Cleveland, Ohio to Knoxville is 401 miles (645.4 km) as the crow flies. Knoxville is located SSW of Cleveland, Ohio. By car, the driving distance is approximately 481.3 miles, taking about 9h 41min. A direct flight would take roughly 1h 18min. Both are located in United States — Cleveland, Ohio in Ohio and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cleveland, Ohio and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.