Clarksdale to Opelousas: Road Trip Guide & Distance

How far is Clarksdale from Opelousas?

The distance from Clarksdale to Opelousas is 268.2 miles (431.7 km) as the crow flies. Opelousas is located SSW of Clarksdale. By car, the driving distance is approximately 335.3 miles, taking about 6h 45min. A direct flight would take roughly 1h 2min. Both are located in United States — Clarksdale in Mississippi and Opelousas in Louisiana.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Clarksdale and Opelousas. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.