Cape Girardeau to Madison, Wisconsin: Road Trip Guide & Distance

How far is Cape Girardeau from Madison, Wisconsin?

The distance from Cape Girardeau to Madison, Wisconsin is 398.5 miles (641.4 km) as the crow flies. Madison, Wisconsin is located N of Cape Girardeau. By car, the driving distance is approximately 478.3 miles, taking about 9h 37min. A direct flight would take roughly 1h 18min. Both are located in United States — Cape Girardeau in Missouri and Madison, Wisconsin in Wisconsin.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Cape Girardeau and Madison, Wisconsin. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.