Cape Girardeau to Knoxville: Road Trip Guide & Distance

How far is Cape Girardeau from Knoxville?

The distance from Cape Girardeau to Knoxville is 323.9 miles (521.3 km) as the crow flies. Knoxville is located ESE of Cape Girardeau. By car, the driving distance is approximately 388.7 miles, taking about 7h 49min. A direct flight would take roughly 1h 9min. Both are located in United States — Cape Girardeau in Missouri and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.