Cape Girardeau to Dothan: Road Trip Guide & Distance

How far is Cape Girardeau from Dothan?

The distance from Cape Girardeau to Dothan is 481.7 miles (775.2 km) as the crow flies. Dothan is located SSE of Cape Girardeau. By car, the driving distance is approximately 578 miles, taking about 11h 38min. A direct flight would take roughly 1h 28min. Both are located in United States — Cape Girardeau in Missouri and Dothan in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Dothan. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.