Cape Girardeau to Cincinnati: Road Trip Guide & Distance

How far is Cape Girardeau from Cincinnati?

The distance from Cape Girardeau to Cincinnati is 298.8 miles (480.8 km) as the crow flies. Cincinnati is located ENE of Cape Girardeau. By car, the driving distance is approximately 373.4 miles, taking about 7h 31min. A direct flight would take roughly 1h 6min. Both are located in United States — Cape Girardeau in Missouri and Cincinnati in Ohio.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Cincinnati. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.