Biloxi to Cape Girardeau: Road Trip Guide & Distance

How far is Biloxi from Cape Girardeau?

The distance from Biloxi to Cape Girardeau is 478.8 miles (770.6 km) as the crow flies. Cape Girardeau is located N of Biloxi. By car, the driving distance is approximately 574.6 miles, taking about 11h 34min. A direct flight would take roughly 1h 28min. Both are located in United States — Biloxi in Mississippi and Cape Girardeau in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Biloxi and Cape Girardeau. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.