Ann Arbor to St. Louis: Road Trip Guide & Distance

How far is Ann Arbor from St. Louis?

The distance from Ann Arbor to St. Louis is 422.8 miles (680.4 km) as the crow flies. St. Louis is located SW of Ann Arbor. By car, the driving distance is approximately 507.3 miles, taking about 10h 12min. A direct flight would take roughly 1h 21min. Both are located in United States — Ann Arbor in Michigan and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Ann Arbor and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.