Lafayette, Indiana to St. Louis: Road Trip Guide & Distance

How far is Lafayette, Indiana from St. Louis?

The distance from Lafayette, Indiana to St. Louis is 216.1 miles (347.7 km) as the crow flies. St. Louis is located SW of Lafayette, Indiana. By car, the driving distance is approximately 270 miles, taking about 5h 26min. A direct flight would take roughly 56min. Both are located in United States — Lafayette, Indiana in Indiana and St. Louis in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Lafayette, Indiana and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.