Tampa to Tupelo: Road Trip Guide & Distance

How far is Tampa from Tupelo?

The distance from Tampa to Tupelo is 571.2 miles (919.2 km) as the crow flies. Tupelo is located NW of Tampa. By car, the driving distance is approximately 685.4 miles, taking about 13h 47min. A direct flight would take roughly 1h 39min. Both are located in United States — Tampa in Florida and Tupelo in Mississippi.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Tampa and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.