Syracuse, New York to Winston-Salem: Road Trip Guide & Distance

How far is Syracuse, New York from Winston-Salem?

The distance from Syracuse, New York to Winston-Salem is 527.2 miles (848.4 km) as the crow flies. Winston-Salem is located SSW of Syracuse, New York. By car, the driving distance is approximately 632.6 miles, taking about 12h 44min. A direct flight would take roughly 1h 34min. Both are located in United States — Syracuse, New York in New York and Winston-Salem in North Carolina.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Syracuse, New York and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.