St. Louis to Winona: Road Trip Guide & Distance

How far is St. Louis from Winona?

The distance from St. Louis to Winona is 382 miles (614.8 km) as the crow flies. Winona is located N of St. Louis. By car, the driving distance is approximately 458.4 miles, taking about 9h 13min. A direct flight would take roughly 1h 16min. Both are located in United States — St. Louis in Missouri and Winona in Minnesota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for St. Louis and Winona. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.