St. Louis to Waterloo, Iowa: Road Trip Guide & Distance

How far is St. Louis from Waterloo, Iowa?

The distance from St. Louis to Waterloo, Iowa is 289.8 miles (466.4 km) as the crow flies. Waterloo, Iowa is located NNW of St. Louis. By car, the driving distance is approximately 362.3 miles, taking about 7h 17min. A direct flight would take roughly 1h 5min. Both are located in United States — St. Louis in Missouri and Waterloo, Iowa in Iowa.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for St. Louis and Waterloo, Iowa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.