Rochester, New York to Winston-Salem: Road Trip Guide & Distance

How far is Rochester, New York from Winston-Salem?

The distance from Rochester, New York to Winston-Salem is 507.3 miles (816.4 km) as the crow flies. Winston-Salem is located SSW of Rochester, New York. By car, the driving distance is approximately 608.8 miles, taking about 12h 15min. A direct flight would take roughly 1h 31min. Both are located in United States — Rochester, New York in New York and Winston-Salem in North Carolina.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Rochester, New York and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.