Port Saint Lucie to San Antonio: Road Trip Guide & Distance

How far is Port Saint Lucie from San Antonio?

The distance from Port Saint Lucie to San Antonio is 1111.8 miles (1789.2 km) as the crow flies. San Antonio is located WNW of Port Saint Lucie. By car, the driving distance is approximately 1273 miles, taking about 23h 1min. A direct flight would take roughly 2h 44min. Both are located in United States — Port Saint Lucie in Florida and San Antonio in Texas.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Port Saint Lucie and San Antonio. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.