Pittsburgh to Winston-Salem: Road Trip Guide & Distance

How far is Pittsburgh from Winston-Salem?

The distance from Pittsburgh to Winston-Salem is 300.2 miles (483.1 km) as the crow flies. Winston-Salem is located S of Pittsburgh. By car, the driving distance is approximately 375.2 miles, taking about 7h 33min. A direct flight would take roughly 1h 6min. Both are located in United States — Pittsburgh in Pennsylvania and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time.

Coordinates come from public place data for Pittsburgh and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.