Pascagoula to Siesta Key: Road Trip Guide & Distance

How far is Pascagoula from Siesta Key?

The distance from Pascagoula to Siesta Key is 422 miles (679.2 km) as the crow flies. Siesta Key is located ESE of Pascagoula. By car, the driving distance is approximately 506.4 miles, taking about 10h 11min. A direct flight would take roughly 1h 21min. Both are located in United States — Pascagoula in Mississippi and Siesta Key in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Pascagoula and Siesta Key. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.