Oxford, Mississippi to Saint Charles, Missouri: Road Trip Guide & Distance

How far is Oxford, Mississippi from Saint Charles, Missouri?

The distance from Oxford, Mississippi to Saint Charles, Missouri is 309.8 miles (498.6 km) as the crow flies. Saint Charles, Missouri is located N of Oxford, Mississippi. By car, the driving distance is approximately 387.3 miles, taking about 7h 47min. A direct flight would take roughly 1h 7min. Both are located in United States — Oxford, Mississippi in Mississippi and Saint Charles, Missouri in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time.

Coordinates come from public place data for Oxford, Mississippi and Saint Charles, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.