Opelousas to Tuscaloosa: Road Trip Guide & Distance

How far is Opelousas from Tuscaloosa?

The distance from Opelousas to Tuscaloosa is 322.9 miles (519.6 km) as the crow flies. Tuscaloosa is located NE of Opelousas. By car, the driving distance is approximately 387.4 miles, taking about 7h 48min. A direct flight would take roughly 1h 9min. Both are located in United States — Opelousas in Louisiana and Tuscaloosa in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Opelousas and Tuscaloosa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.