Opelika to Winston-Salem: Road Trip Guide & Distance

How far is Opelika from Winston-Salem?

The distance from Opelika to Winston-Salem is 377.7 miles (607.8 km) as the crow flies. Winston-Salem is located NE of Opelika. By car, the driving distance is approximately 453.2 miles, taking about 9h 7min. A direct flight would take roughly 1h 16min. Both are located in United States — Opelika in Alabama and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Opelika and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.