Opelika to Tupelo: Road Trip Guide & Distance

How far is Opelika from Tupelo?

The distance from Opelika to Tupelo is 221.8 miles (356.9 km) as the crow flies. Tupelo is located WNW of Opelika. By car, the driving distance is approximately 277.2 miles, taking about 5h 35min. A direct flight would take roughly 57min. Both are located in United States — Opelika in Alabama and Tupelo in Mississippi.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Opelika and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.