O'Fallon, Missouri to Portsmouth, Ohio: Road Trip Guide & Distance

How far is O'Fallon, Missouri from Portsmouth, Ohio?

The distance from O'Fallon, Missouri to Portsmouth, Ohio is 414.8 miles (667.6 km) as the crow flies. Portsmouth, Ohio is located E of O'Fallon, Missouri. By car, the driving distance is approximately 497.8 miles, taking about 10h 1min. A direct flight would take roughly 1h 20min. Both are located in United States — O'Fallon, Missouri in Missouri and Portsmouth, Ohio in Ohio.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for O'Fallon, Missouri and Portsmouth, Ohio. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.