Muscatine to Springfield, Missouri: Road Trip Guide & Distance

How far is Muscatine from Springfield, Missouri?

The distance from Muscatine to Springfield, Missouri is 314.8 miles (506.6 km) as the crow flies. Springfield, Missouri is located SSW of Muscatine. By car, the driving distance is approximately 377.7 miles, taking about 7h 36min. A direct flight would take roughly 1h 8min. Both are located in United States — Muscatine in Iowa and Springfield, Missouri in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Muscatine and Springfield, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.