Middletown, Ohio to Winston-Salem: Road Trip Guide & Distance

How far is Middletown, Ohio from Winston-Salem?

The distance from Middletown, Ohio to Winston-Salem is 327.2 miles (526.6 km) as the crow flies. Winston-Salem is located SE of Middletown, Ohio. By car, the driving distance is approximately 392.6 miles, taking about 7h 54min. A direct flight would take roughly 1h 9min. Both are located in United States — Middletown, Ohio in Ohio and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Middletown, Ohio and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.