Middletown, Ohio to Spartanburg: Road Trip Guide & Distance

How far is Middletown, Ohio from Spartanburg?

The distance from Middletown, Ohio to Spartanburg is 343.4 miles (552.6 km) as the crow flies. Spartanburg is located SSE of Middletown, Ohio. By car, the driving distance is approximately 412 miles, taking about 8h 17min. A direct flight would take roughly 1h 11min. Both are located in United States — Middletown, Ohio in Ohio and Spartanburg in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Middletown, Ohio and Spartanburg. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.