Middletown, Ohio to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Middletown, Ohio from O'Fallon, Missouri?

The distance from Middletown, Ohio to O'Fallon, Missouri is 341 miles (548.8 km) as the crow flies. O'Fallon, Missouri is located W of Middletown, Ohio. By car, the driving distance is approximately 409.2 miles, taking about 8h 14min. A direct flight would take roughly 1h 11min. Both are located in United States — Middletown, Ohio in Ohio and O'Fallon, Missouri in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Middletown, Ohio and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.