Mesquite to Odessa: Road Trip Guide & Distance

How far is Mesquite from Odessa?

The distance from Mesquite to Odessa is 749.6 miles (1206.4 km) as the crow flies. Odessa is located ESE of Mesquite. By car, the driving distance is approximately 899.6 miles, taking about 18h 6min. A direct flight would take roughly 2h 0min. Both are located in United States — Mesquite in Nevada and Odessa in Texas.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Mesquite and Odessa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.