Madison, Wisconsin to St. Louis: Road Trip Guide & Distance

How far is Madison, Wisconsin from St. Louis?

The distance from Madison, Wisconsin to St. Louis is 310 miles (498.9 km) as the crow flies. St. Louis is located S of Madison, Wisconsin. By car, the driving distance is approximately 387.5 miles, taking about 7h 48min. A direct flight would take roughly 1h 7min. Both are located in United States — Madison, Wisconsin in Wisconsin and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time.

Coordinates come from public place data for Madison, Wisconsin and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.