Louisville to Tupelo: Road Trip Guide & Distance

How far is Louisville from Tupelo?

The distance from Louisville to Tupelo is 321.1 miles (516.7 km) as the crow flies. Tupelo is located SSW of Louisville. By car, the driving distance is approximately 386.4 miles, taking about 7h 27min. A direct flight would take roughly 1h 9min. Both are located in United States — Louisville in Kentucky and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Louisville and Tupelo. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.