Louisville to St. Louis: Road Trip Guide & Distance

How far is Louisville from St. Louis?

The distance from Louisville to St. Louis is 241.7 miles (389 km) as the crow flies. St. Louis is located W of Louisville. By car, the driving distance is approximately 259.9 miles, taking about 4h 50min. A direct flight would take roughly 59min. Both are located in United States — Louisville in Kentucky and St. Louis in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Louisville and St. Louis. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.