Louisville to Opelika: Road Trip Guide & Distance

How far is Louisville from Opelika?

The distance from Louisville to Opelika is 388 miles (624.5 km) as the crow flies. Opelika is located S of Louisville. By car, the driving distance is approximately 476.3 miles, taking about 9h 4min. A direct flight would take roughly 1h 17min. Both are located in United States — Louisville in Kentucky and Opelika in Alabama.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Louisville and Opelika. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.