Lexington, Kentucky to Tupelo: Road Trip Guide & Distance

How far is Lexington, Kentucky from Tupelo?

The distance from Lexington, Kentucky to Tupelo is 351 miles (564.8 km) as the crow flies. Tupelo is located SW of Lexington, Kentucky. By car, the driving distance is approximately 421.2 miles, taking about 8h 28min. A direct flight would take roughly 1h 12min. Both are located in United States — Lexington, Kentucky in Kentucky and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Lexington, Kentucky and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.