Lafayette, Louisiana to Tupelo: Road Trip Guide & Distance

How far is Lafayette, Louisiana from Tupelo?

The distance from Lafayette, Louisiana to Tupelo is 339.4 miles (546.2 km) as the crow flies. Tupelo is located NE of Lafayette, Louisiana. By car, the driving distance is approximately 407.2 miles, taking about 8h 12min. A direct flight would take roughly 1h 11min. Both are located in United States — Lafayette, Louisiana in Louisiana and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Lafayette, Louisiana and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.