La Crosse to Sioux City: Road Trip Guide & Distance

How far is La Crosse from Sioux City?

The distance from La Crosse to Sioux City is 275.2 miles (442.9 km) as the crow flies. Sioux City is located WSW of La Crosse. By car, the driving distance is approximately 344 miles, taking about 6h 55min. A direct flight would take roughly 1h 3min. Both are located in United States — La Crosse in Wisconsin and Sioux City in Iowa.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for La Crosse and Sioux City. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.