La Crosse to Muscatine: Road Trip Guide & Distance

How far is La Crosse from Muscatine?

The distance from La Crosse to Muscatine is 164.5 miles (264.8 km) as the crow flies. Muscatine is located S of La Crosse. By car, the driving distance is approximately 205.7 miles, taking about 4h 8min. A direct flight would take roughly 50min. Both are located in United States — La Crosse in Wisconsin and Muscatine in Iowa.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for La Crosse and Muscatine. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.