Knoxville to Opelika: Road Trip Guide & Distance

How far is Knoxville from Opelika?

The distance from Knoxville to Opelika is 243.7 miles (392.2 km) as the crow flies. Opelika is located SSW of Knoxville. By car, the driving distance is approximately 304.7 miles, taking about 6h 8min. A direct flight would take roughly 59min. Both are located in United States — Knoxville in Tennessee and Opelika in Alabama.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Knoxville and Opelika. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.