Knoxville to Myrtle Beach: Road Trip Guide & Distance

How far is Knoxville from Myrtle Beach?

The distance from Knoxville to Myrtle Beach is 325.7 miles (524.2 km) as the crow flies. Myrtle Beach is located ESE of Knoxville. By car, the driving distance is approximately 390.8 miles, taking about 7h 52min. A direct flight would take roughly 1h 9min. Both are located in United States — Knoxville in Tennessee and Myrtle Beach in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Knoxville and Myrtle Beach. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.