Knoxville to Medina: Road Trip Guide & Distance

How far is Knoxville from Medina?

The distance from Knoxville to Medina is 374.6 miles (602.8 km) as the crow flies. Medina is located NNE of Knoxville. By car, the driving distance is approximately 449.5 miles, taking about 9h 3min. A direct flight would take roughly 1h 15min. Both are located in United States — Knoxville in Tennessee and Medina in Ohio.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Knoxville and Medina. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.