Key West to Sanford, Florida: Road Trip Guide & Distance

How far is Key West from Sanford, Florida?

The distance from Key West to Sanford, Florida is 295 miles (474.8 km) as the crow flies. Sanford, Florida is located N of Key West. By car, the driving distance is approximately 368.8 miles, taking about 7h 25min. A direct flight would take roughly 1h 6min. Both are located in United States.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time.

Coordinates come from public place data for Key West and Sanford, Florida. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.